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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
50.3
Human Site:
Y407
Identified Species:
73.78
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
T
V
Chimpanzee
Pan troglodytes
XP_509931
527
59578
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
T
V
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
Y410
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
I
V
Dog
Lupus familis
XP_851216
527
59504
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
I
V
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
I
I
Rat
Rattus norvegicus
XP_216727
527
59187
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
Y415
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
I
V
Chicken
Gallus gallus
Q5ZKQ6
527
59609
Y407
T
N
P
C
R
V
Q
Y
C
T
Q
E
I
I
I
Frog
Xenopus laevis
NP_001083783
527
59670
Y407
T
N
P
C
R
I
Q
Y
C
T
Q
E
I
V
V
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
Y407
T
N
P
C
R
I
Q
Y
C
S
Q
E
L
V
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
Y403
T
N
P
C
R
L
Q
Y
C
T
Q
Q
I
V
V
Honey Bee
Apis mellifera
XP_001120791
454
52119
L339
C
T
K
E
I
V
V
L
R
E
D
I
L
T
K
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
A396
N
P
C
R
I
Q
F
A
S
Q
E
I
V
V
F
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
Y379
T
N
P
C
R
L
Q
Y
C
T
Q
E
I
I
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
F413
S
N
P
C
R
V
K
F
Y
T
Q
E
I
V
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
Y534
S
N
P
T
R
I
A
Y
L
S
Q
E
I
V
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
86.6
N.A.
93.3
80
93.3
73.3
N.A.
80
6.6
0
86.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
93.3
N.A.
93.3
20
13.3
93.3
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
53.3
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
80
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% A
% Cys:
7
0
7
82
0
0
0
0
75
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% D
% Glu:
0
0
0
7
0
0
0
0
0
7
7
82
0
0
0
% E
% Phe:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
13
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
13
63
0
0
0
0
0
13
82
44
32
% I
% Lys:
0
0
7
0
0
0
7
0
0
0
0
0
0
0
7
% K
% Leu:
0
0
0
0
0
13
0
7
7
0
0
0
13
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
88
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
7
88
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
7
75
0
0
7
88
7
0
0
0
% Q
% Arg:
0
0
0
7
88
0
0
0
7
0
0
0
0
0
0
% R
% Ser:
13
0
0
0
0
0
0
0
7
13
0
0
0
0
0
% S
% Thr:
75
7
0
7
0
0
0
0
0
75
0
0
0
19
0
% T
% Val:
0
0
0
0
0
19
7
0
0
0
0
0
7
38
50
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
82
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _